DOI: 10.1182/blood.2023020619 ISSN:

Identifying STRN3-RARA as a new fusion gene for acute promyelocytic leukemia

Qi Zhang, He Li, Xuelan Chen, Fan Gu, Lanxin Zhang, Lu Zhang, Tong Chen, Qiang Chen, Wentong Meng, Yu Wu, Hong Chang, Ting Liu, Chong Chen, Hongbing Ma, Yu Liu
  • Cell Biology
  • Hematology
  • Immunology
  • Biochemistry
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Here we report a new fusion gene, STRN3-RARA, in acute promyelocytic leukemia (APL). It cooperates with UTX deficiency to drive full-blown APL in mice. While STRN3-RARA leukemia quickly relapses after ATRA treatment, they can be restrained by cepharanthine.

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