DOI: 10.1002/jbio.202300348 ISSN: 1864-063X

Effectiveness of 780 nm photobiomodulation as adjunct treatment for bone exposed fractures: A pilot study on radiograph, pain, and cytokines analysis

Deivison Santos Bonfim, Micaela Leite Fernandes, Igor Pereira Ribeiro Muniz, Ítalo Sousa Pereira, Robson Amaro Augusto da Silva, Francine Cristina da Silva, Luciano Pereira Rosa, Gabriel Pinto de Oliveira Santos
  • General Physics and Astronomy
  • General Engineering
  • General Biochemistry, Genetics and Molecular Biology
  • General Materials Science
  • General Chemistry


The aim of this study was to evaluate the effectiveness of photobiomodulation with a 780 nm laser as an adjunct to surgical treatment in the regeneration of bone fractures. Twenty patients diagnosed with open fractures in the lower limbs were selected and randomly divided into two groups: control and LLLT. LLLT parameter: 780 nm, 0.04 cm2 of light beam diameter, 40 mW of power, 10 s per point, 0.4 J of energy, fluence of 10 J/cm2 and irradiance of 1 W/cm2. The evaluated data were: pain, using McGill scale, use of analgesics and anti‐inflammatories, levels of cytokines TNF‐α, IFN‐γ, IL‐1β, IL‐10, and IL‐17, and bone level regeneration. Data were analyzed using Wilcoxon and Mann–Whitney tests (5%). We can conclude that LLLT was effective as an adjuvant in the bone fracture regeneration process, altered IL‐1β levels, reduced the use of analgesics and anti‐inflammatories, reducing the pain pattern throughout the sessions.

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