DOI: 10.1093/bioinformatics/btae144 ISSN: 1367-4811

Digger: Directed annotation of immunoglobulin and T cell receptor V, D and J gene sequences and assemblies

William D Lees, Swati Saha, Gur Yaari, Corey T Watson
  • Computational Mathematics
  • Computational Theory and Mathematics
  • Computer Science Applications
  • Molecular Biology
  • Biochemistry
  • Statistics and Probability



Knowledge of immunoglobulin and T cell receptor encoding genes is derived from high-quality genomic sequencing. High throughput sequencing is delivering large volumes of data, and precise, high-throughput approaches to annotation are needed. Digger is an automated tool that identifies coding and regulatory regions of these genes, with results comparable to those obtained by current expert curational methods.

Availability and Implementation

Digger is published under open source licence at and is available as a Python package and a Docker container.

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