DOI: 10.1111/bjh.19217 ISSN: 0007-1048

Characteristics and long‐term outcome in a large series of chronic myelomonocytic leukaemia patients including 104 formerly referred to as oligomonocytic

Sandra Castaño‐Díez, Helena Pomares, Daniel Esteban, Francesca Guijarro, Carlos Jiménez‐Vicente, Inés Zugasti, José Ramón Álamo, Víctor Torrecillas Mayayo, Mònica López‐Guerra, Cristina de la Fuente, Paola Charry, Albert Cortés‐Bullich, Álex Bataller, Clara Maluquer, Dolors Colomer, María Rozman, Montserrat Arnan, Blanca Xicoy, Jordi Esteve, Marina Díaz‐Beyá
  • Hematology


Recently modified diagnostic criteria for chronic myelomonocytic leukaemia (CMML) have lowered the cut‐off for absolute monocytosis. In the largest series to date, we have analysed 313 CMML patients, including 104 with oligomonocytic (OM)‐CMML. Five‐year survival was longer for OM‐CMML than for other patients (p < 0.001). Multivariate analysis identified OM‐CMML as a favourable prognostic factor (HR 0.58; p = 0.002). The 5‐year cumulative incidence of progression to classical CMML was 47%. Older age and transfusion dependence were adverse prognostic factors for OM‐CMML. Our results support the inclusion of OM‐CMML in the CMML category as a subtype with superior outcomes.

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