DOI: 10.1093/bjs/znad258.345 ISSN:

602 Bilateral Warthin's Tumour of the Parotid Gland: A 16-Year Retrospective Analysis and Systematic Review

A Gupta, Z Siddiqui, R H K Nam, R C T Huynh, M Jan, K Dusu, V Dhar
  • Surgery



Warthin’s tumour (WT) is the second most common benign parotid tumour in the United Kingdom. The World Health Organisation (WHO) states that WTs are bilateral in 5-14% of patients. However, current medical literature varies significantly more. We aim to assess the frequency of bilateral WTs over the last 16 years at a large head and neck unit in Kent, England and to perform the first systematic review of literature on bilateral WTs.


A single-centre retrospective analysis of patients who were diagnosed with WT on histology between January 1st, 2005, and December 31st, 2020 was conducted. A systematic review (PROSPERO Registration Number: CRD42022326846) of literature was performed using PubMed and the Cochrane Library. The inclusion criteria were full-text published studies in English describing patients, at any age, who were diagnosed with bilateral WTs.


290 patients (112 females) diagnosed with WTs were included in our retrospective analysis. 24.5% of our patients had bilateral WTs. WTs in female patients were bilateral in 28.6% of cases and 21.9% in male patients. Our systematic review identified 157 papers, of which 14 met our inclusion/exclusion criteria. These studies reported the prevalence of bilateral WTs to range from 0.65% to 40% and the mean was 12.5%.


Our study showed that 1 in 4 of our patients had bilateral WTs and nearly a third of WTs in females were bilateral. This varies significantly from the WHO guidelines (5-14% bilateral WTs). This will be of interest to surgeons who discuss this disease with future patients.

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