151 How Do Mortality Rates From COVID-19 Differ Between Vaccinated and Unvaccinated People in a Tertiary Centre of Bangladesh

Aim

To find out the difference in mortality rates between vaccinated and unvaccinated COVID-19 positive patients who admitted in a tertiary center (Ward Vs Intensive care) of Bangladesh.

Method

Retrospective analysis of data over 6 weeks (February- March 2021).

100 confirmed COVID-19 positive patients were included- 50 from ICU (Intensive Care Unit) and 50 from ward irrespective of age, gender, vaccination status and comorbidities.

Results

75% of all confirmed COVID 19 positive patients were vaccinated. Mortality among vaccinated people was less compared to unvaccinated 41.3% Vs 52%.

Interestingly pregnancy was found to be the most significant risk factor in child-bearing age female group- 86.7% of pregnant and peripartum female required ICU admission and mortality was 40% although none of them had any co-morbidities. Again, mortality among vaccinated was significantly less (35.7%) compared to 100% mortality among unvaccinated.

Mortality rate among ICU admitted patients was significantly high- 72% Vs 16%.

83% of patients who died in ICU were vaccinated (90% had 2 doses, 10% had 3 doses). 87.5% who died in ward were unvaccinated.

Among the survivors from ICU - 93% were vaccinated (Vs 7% unvaccinated).

Overall, pre-existing comorbidities increased mortality by 18.1% (59% Vs 40.9%).

Conclusions

Vaccination against COVID-19 reduces mortality irrespective of co-morbidities or disease severity. Recovery rate was significantly increased in vaccinated ICU admitted patients.

Pregnancy was found to be the most important risk factor for ICU admission and mortality in otherwise healthy child-bearing age females and mortality was 100% (limited data availability) in unvaccinated.

These results require further revalidation on larger population.