The emerging role of miR-320a in lung cancer: a comprehensive review
Adrija Mohanta, Rajiv R Kumar, Rahul K Singh, Surojit Mandal, Ritu Yadav, Rinku Khatkar, Uttam Sharma, Vivek Uttam, Manjit K Rana, Amrit PS Rana, Aklank Jain- Biochemistry (medical)
- Clinical Biochemistry
- Drug Discovery
A specialized biomarker(s) for lung cancer is imperative owing to its high mortality. Continuing our earlier work demonstrating the role of miR-320a as a tumor suppressor, here we discuss the most recent updates on miR-320a in lung cancer pathogenesis. We found that miR-320a modulates levels of diverse cancer-associated molecules and signaling pathways, and is also involved in modulating the immune microenvironment of lung cancer during its pathogenesis. We also discuss how miR-320a encapsulated in exosomes inhibits invasive phenotypes of lung cancer. Therefore, based on the multimodal role of miR-320a in lung cancer development and progression, we believe that miR-320a may be utilized as a potential diagnostic/prognostic marker and therapeutic target for lung cancer patients.