Synthesis of some spiro[chromane-2,3ʹ-pyrrolidine]-4-one derivatives and investigation of their antifungal activity

Eleven spiro[chromane-2,3ʹ-pyrrolidine]-4-one derivatives were synthesized, and their antifungal activity against Candida albicans and Cryptococcus neoformans was tested. Among synthesized derivatives, one antifungal-active substance was revealed – 6-fluorospiro[chromane-2,3ʹ-pyrrolidine]-4-one hydrochloride inhibiting growth of Cryptococcus neoformans with the MIC value 16 μg/ml. This compound demonstrates no cytotoxicity or hemolytic activity against human cell line HEK-293 and red blood cells