DOI: 10.1039/d3cb00093a ISSN:
RiPP enzyme heterocomplex structure-guided discovery of a bacterial borosin α-N-methylated peptide natural product
K. K. Crone, T. Jomori, F. S. Miller, J. A. Gralnick, M. H. Elias, M. F. Freeman- Biochemistry, Genetics and Molecular Biology (miscellaneous)
- Molecular Biology
- Biochemistry
- Chemistry (miscellaneous)
Through a combination of in vitro structure–activity assays, crystallography, and in vivo knockout experiments, we have identified and structurally characterized the first bacterial borosin natural product.