Research on the synthetic methodology for lurasidone hydrochloride

In this study, the antipsychotic drug Ruprasidone hydrochloride was synthesized using (1R,2R)-1, 2cyclohexanedimethanol as the starting material. The synthesis process was carried out through four steps : sulfonylation, N-alkylation, substitution and acidification with hydrochloric acid. Eventually, lurasidone hydrochloride was obtained with a total yield of 34.3% (calculated based on (1R,2R)-1, 2-cyclohexanedimethanol). The structure of the target compound was confirmed by 1 H-NMR and 13 C-NMR spectroscopic analysis. The synthetic process of this reported has the advantages of high yield, simple steps, high costeffectiveness and safe operation, and the synthetic process is suitable for industrial production. This study provides a methodological reference for the industrial manufacturing of ruprasidone hydrochloride.