DOI: 10.1002/vjch.202000068 ISSN: 2572-8288

Phenolic compounds from Trigonostemon honbaensis and their cytotoxic activity

Ninh Khac Ban, Luu Hong Truong, Tran My Linh, Nguyen Chi Mai, Duong Thi Hai Yen, Vu Van Doan, Nguyen Xuan Nhiem, Bui Huu Tai, Phan Van Kiem
  • Marketing
  • Strategy and Management
  • General Materials Science
  • Media Technology


Seven phenolic compounds including (±)‐erythro‐1‐(3′,4′,5′‐trimethoxyphenyl)propane‐1,2‐diol (1), (±)‐threo‐1‐(3′,4′,5′‐trimethoxyphenyl)propane‐1,2‐diol (2), (R)‐3‐3‐(3′,4′‐dimethoxyphenyl)propane‐1,2‐diol (3), (±)‐3‐(3′,4′,5′‐trimethoxyphenyl)propane‐1,2‐diol (4), (+)‐syringaresinol (5), (7S,8R,8′R)‐5,5′‐dimethoxylariciresinol (6), juniperoside (7) were isolated from the leaves of Trigonostemon honbaensis. Their chemical structures were determined using ESI‐MS, 1D NMR, and 2D NMR spectra and in comparison with the reported literature. Compounds17 were reported from Trigonostemongenus for the first time. At concentration of 30 μM, compounds 17 exhibited weak cytotoxic activity with cell viability percentages as low as 73.3±0.87 % and 79.5±0.23 % on CAL‐27 and MDA‐MB231 cell lines, respectively.

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