DOI: 10.1002/gcc.23222 ISSN: 1045-2257

Near complete remission of an inoperable pancreatic acinar cell carcinoma after BRAF‐/MEK‐inhibitor treatment—A case report and review of the literature

Lennart von Fritsch, Nikolas von Bubnoff, Klaus Weber, Jutta Kirfel, Cleopatra Schreiber, Tobias Keck, Ulrich Wellner
  • Cancer Research
  • Genetics



Pancreatic acinar cell carcinomas are rare malignant neoplasms. High‐quality evidence about the best treatment strategy is lacking. We present the case of a 52‐year‐old male with a BRAFV600E‐mutated PACC who experienced a complete remission after chemotherapy with BRAF‐/MEK‐inhibitors.


The patient presented with upper abdomen pain, night sweat, and weight loss. CT scan showed a pancreatic tumor extending from the pancreas head to body. Histological workup identified an acinar cell carcinoma. As the tumor was inoperable, chemotherapy with FOFIRNIOX was initiated and initially showed a slight regression of disease. The regimen had to be discontinued due to severe side effects. Molecular analysis identified a BRAFV600E mutation, so the patient was started on BRAF‐ and MEK‐inhibitors (dabrafenib/trametinib). After 16 months, CT scans showed a near complete remission with a markedly improved overall health.


Studies suggest that up to one‐fourth of PACCs carry a BRAF mutation and might therefore be susceptible to a BRAF‐/MEK‐inhibitor therapy. This offers a new therapeutic pathway to treat this rare but malignant neoplasm.

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