Microwave-Assisted Synthesis of Imidazole Derivatives: A Recent Update

Abstract:

Microwave-assisted synthesis has emerged as a sustainable and eco-friendly approach for the rapid and efficient production of organic compounds. This technique offers significant advantages over conventional methods, including shorter reaction times, enhanced yields, and improved product purity. The uniform heating provided by microwave radiation is particularly beneficial for the synthesis of heterocyclic compounds and their derivatives. Among these, imidazole derivatives hold great pharmaceutical and biological significance. In light of this, the present review focuses on recent solvent-free, acid-mediated, ionic liquid-mediated, NPs-catalyzed, and metal-catalyzed microwave-assisted methods for the synthesis of these molecules.