DOI: 10.1002/ajoc.202300495 ISSN: 2193-5807
Lewis Base Catalyzed C‐S Bond Formation through Methyl C(sp3)‐H Thiocyanation of Indoles
Qumruddeen ., Dileep Kumar, Jobsy Jose, CHANDRA BHUSHAN TRIPATHI- Organic Chemistry
A Lewis base catalyzed C‐S bond formation through thiocyanation of methyl C(sp3)‐H bond is reported. The method involves a sequential chlorination and thiocyanation reaction. This simple yet effective protocol works with diverse array of indoles to furnish thiocyanated products in good yield (up to 85%). The developed method is also applied for the synthesis of phercaptoline (hypotensive agent) and umifenovir (antiviral drug).