Lucrezia Margherita Comparini, Andrea Menichetti, Lucilla Favero, Sebastiano Di Pietro, Fabrizio Badalassi, Per Ryberg, Mauro Pineschi

Development of an asymmetric formal synthesis of (−)-quinagolide via enzymatic resolution and stereoselective iminium ion reduction

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

The study of the reduction of a benzo[g]octahydroquinolinium ion was examined in detail under different perspectives until we found a viable solution to get an advanced chiral intermediate of (3S,4aS,10aR)-(−)-quinagolide as a single stereoisomer.

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