DOI: 10.1002/ejoc.202301130 ISSN: 1434-193X
Concise Synthesis of Thiazolo[4,5‐b]indoles via Ring Switch/Cyclization Sequences
Koji Yamada, Tetsu Tsubogo, Hikaru Kanazawa, Sayaka Ishizuka, Koutaro Ohyama, Masaki Kaida, Takumi Abe- Organic Chemistry
- Physical and Theoretical Chemistry
Abstract
The unexpected reactions of indoline hemiaminals affords 2,5‐diaryl‐4‐hydroxythiazolines through a thioamidation/ring switch sequence. The key to success of this transformation is to use a thioamide as a thiazoline precursor under transient tautomeric control. This transformation features mild reaction conditions and good yields with broad functional group tolerance (17 examples, up to 99 % yield). Further transformations of the thiazolines provide a direct entry to dihydrothiazolo[4,5‐b]indoles and thiazolo[4,5‐b]indoles.