Clinical and histologic findings after use of a novel combined retinol, tripeptide, and glaucine containing cream in the treatment of photo‐aged skin
Shikha Rao, David Goldberg - Dermatology
Abstract
Background
Neck skin is thinner and has a more delicate dermal layer than facial skin. The studied product was specifically formulated for the neck combining a hydrating delivery system with a trifunctional corrective technology composed of 0.2% pure retinol, 2.5% tripeptide concentrate, and 5.0% glaucine complex to help improvement in signs of aging.
Objectives
To evaluate cosmetic and histologic changes 3 months after treatment using immunostains for Type I collagen, Type III collagen, and glycosaminoglycan (GAGS). In addition, overall clinical improvement in photoaged skin was measured by both Griffith's photonumeric photoaging scale, photographic improvement, and questionnaires.
Methods
This study was an open‐label, blinded clinical trial evaluating a combined retinol, tripeptide, and glaucine containing cream in the treatment of photo‐aged skin. The study enrolled a total of 20 healthy male or female subjects, who applied the product for 3 months to their face and neck.
Results
Clinical as well histologic changes were consistent with improvement in all 20 subjects.
Conclusion
Use of a combined retinol, tripeptide, and glaucine containing cream led to both clinical and histologic improvement of phototoaging.