Catalyst-free assembly of a polyfunctionalized 1,2,4-triazole-fused N-heterocycle, 6-acylated pyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine

Highly efficient access to a 1,2,4-triazole-fused pyrrolo[1,2-a]pyrazine skeleton with various substituents at the C2 and C6 sites was achieved from N-substituted pyrrole-2-carbonitrile under catalyst-free conditions leading to the consecutive formation of pyrazine and 1,2,4-triazole rings.