DOI: 10.1039/d3np00030c ISSN: 0265-0568
Bacterial cyclophane-containing RiPPs from radical SAM enzymes
Chin-Soon Phan, Brandon I. Morinaka- Organic Chemistry
- Drug Discovery
- Biochemistry
This report highlights recent reports of bacteria-derived cyclophane-containing peptides from radical SAM/SPASM enzymes. The strategies for discovery, structures of the products, bioactivity, mechanism of formation, and synthesis are discussed.