DOI: 10.1002/vjch.202000099 ISSN: 2572-8288

Anti‐inflammatory metabolites from a marine sponge‐associated fungus Aspergillus sp. IMBC‐FP2.05

Tran Hong Quang, Le Thi Vien, Le Ngoc Anh, Nguyen Thi Thanh Ngan, Tran Thi Hong Hanh, Nguyen Xuan Cuong, Nguyen Hoai Nam, Chau Van Minh
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Chemical investigation of the marine sponge‐derived fungal strain Aspergillus sp. IMBC‐FP2.05 resulted in isolation of five compounds, including JBIR‐74 (1), homogentisic acid (2), methyl (2,5‐dihydroxyphenyl)acetate (3), 3‐chloro‐2,5‐dihydroxybenzyl alcohol (4), and p‐hydroxybenzaldehyde (5). Their chemical structures were identified by comprehensive analyses of the 1D and 2D NMR and mass spectra in comparison with the previously reported data. Furthermore, nitric oxide (NO) inhibitory effects of the isolated compounds in LPS‐stimulated RAW264.7 cells were also reported.

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