AbstractThe marine red algal genus Laurencia has abundant halogenated secondary metabolites, which exhibit novel structural types and possess various unique biological potentials, including antifouling activity. In this study, we report the isolation, structure elucidation, and antifouling activities of two novel brominated diterpenoids, aplysin‐20 aldehyde (1), 13‐dehydroxyisoaplysin‐20 (2), and its congeners. We screened marine red alga Laurencia venusta Yamada for their antifouling activity against the mussel Mytilus galloprovincialis. Ethyl acetate extracts of L. venusta from Hiroshima and Chiba, Japan, were isolated and purified, and the compound structures were identified using 1D and 2D NMR, HR‐APCI‐MS, IR, and chemical synthesis. Seven secondary metabolites were identified, and their antifouling activities were evaluated. Compounds 1, 2, and aplysin‐20 (3) exhibited strong activities against M. galloprovincialis. Therefore, these compounds can be explored as natural antifouling drugs.

More from our Archive

• DOI: 10.1093/bib/bbad259 2023

  Predicting metabolite–disease associations based on auto-encoder and non-negative matrix factorization

  Hongyan Gao, Jianqiang Sun, Yukun Wang, Yuer Lu, Liyu Liu, Qi Zhao, Jianwei Shuai

• DOI: 10.3390/biom13071152 2023

  Electrospun Biomolecule-Based Drug Delivery Systems

  Deng-Guang Yu, Chang Huang

• DOI: 10.1002/jbt.23482 2023

  From nature to therapy: Luteolin's potential as an immune system modulator in inflammatory disorders

  Md Sadique Hussain, Gaurav Gupta, Ahsas Goyal, Riya Thapa, Waleed Hassan almalki, Imran Kazmi, Sami I. Alzarea, Shivkanya Fuloria, Dhanalekshmi Unnikrishnan Meenakshi, Vikas Jakhmola, Manisha Pandey, Sachin Kumar Singh, Kamal Dua

• DOI: 10.3390/ijms241512470 2023

  A Systematic Review on the Continuous Cropping Obstacles and Control Strategies in Medicinal Plants

  Muhammad Zeeshan Ul Haq, Jing Yu, Guanglong Yao, Huageng Yang, Hafiza Amina Iqbal, Hassam Tahir, Hongguang Cui, Ya Liu, Yougen Wu

• DOI: 10.3390/ijms241511939 2023

  Spinal Muscular Atrophy: The Past, Present, and Future of Diagnosis and Treatment

  Hisahide Nishio, Emma Tabe Eko Niba, Toshio Saito, Kentaro Okamoto, Yasuhiro Takeshima, Hiroyuki Awano

• DOI: 10.1093/bioinformatics/btad438 2023

  DeepTraSynergy: drug combinations using multimodal deep learning with transformers

  Fatemeh Rafiei, Hojjat Zeraati, Karim Abbasi, Jahan B Ghasemi, Mahboubeh Parsaeian, Ali Masoudi-Nejad

• DOI: 10.3390/ijms241512371 2023

  Strategic Design and Synthesis of Ferrocene Linked Porous Organic Frameworks toward Tunable CO2 Capture and Energy Storage

  Aya Osama Mousa, Cheng-Hsin Chuang, Shiao-Wei Kuo, Mohamed Gamal Mohamed

• DOI: 10.3390/ijms241511910 2023

  The Effect of Metal Ions (Fe, Co, Ni, and Cu) on the Molecular-Structural, Protein Binding, and Cytotoxic Properties of Metal Pyridoxal-Thiosemicarbazone Complexes

  Violeta Jevtovic, Asma K. Alshamari, Dejan Milenković, Jasmina Dimitrić Marković, Zoran Marković, Dušan Dimić

• DOI: 10.3390/ijms241411680 2023

  Bacterial Biofilm Formation on Biomaterials and Approaches to Its Treatment and Prevention

  Panxin Li, Rui Yin, Juanli Cheng, Jinshui Lin

• DOI: 10.1002/prot.26550 2023

  <scp>RNA</scp> target highlights in <scp>CASP15</scp>: Evaluation of predicted models by structure providers

  Rachael C. Kretsch, Ebbe S. Andersen, Janusz M. Bujnicki, Wah Chiu, Rhiju Das, Bingnan Luo, Benoît Masquida, Ewan K. S. McRae, Griffin M. Schroeder, Zhaoming Su, Joseph E. Wedekind, Lily Xu, Kaiming Zhang, Ivan N. Zheludev, John Moult, Andriy Kryshtafovych