DOI: 10.1002/jbt.23482 ISSN: 1095-6670

From nature to therapy: Luteolin's potential as an immune system modulator in inflammatory disorders

Md Sadique Hussain, Gaurav Gupta, Ahsas Goyal, Riya Thapa, Waleed Hassan almalki, Imran Kazmi, Sami I. Alzarea, Shivkanya Fuloria, Dhanalekshmi Unnikrishnan Meenakshi, Vikas Jakhmola, Manisha Pandey, Sachin Kumar Singh, Kamal Dua
  • Health, Toxicology and Mutagenesis
  • Toxicology
  • Molecular Biology
  • Molecular Medicine
  • Biochemistry
  • General Medicine


Inflammation is an essential immune response that helps fight infections and heal tissues. However, chronic inflammation has been linked to several diseases, including cancer, autoimmune disorders, cardiovascular diseases, and neurological disorders. This has increased interest in finding natural substances that can modulate the immune system inflammatory signaling pathways to prevent or treat these diseases. Luteolin is a flavonoid found in many fruits, vegetables, and herbs. It has been shown to have anti‐inflammatory effects by altering signaling pathways in immune cells. This review article discusses the current research on luteolin's role as a natural immune system modulator of inflammatory signaling mechanisms, such as its effects on nuclear factor‐kappa B, mitogen‐activated protein kinases, Janus kinase/signal transducer and activator of transcription, and inflammasome signaling processes. The safety profile of luteolin and its potential therapeutic uses in conditions linked to inflammation are also discussed. Overall, the data point to Luteolin's intriguing potential as a natural regulator of immune system inflammatory signaling processes. More research is needed to fully understand its mechanisms of action and possible therapeutic applications.

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