Abstract: In-depth research is being carried out on mangrove communities, which are regarded as significant habitats for biodiversity, in order to find novel secondary metabolites with useful pharmaceutical and medicinal uses. According to a growing number of articles that point to the enormous potential of this ecological niche, mangrove-associated fungi are acknowledged as a rich source of bioactive chemicals. The fungi Aspergillus sp., Penicillium sp., and Fusarium sp., which are isolated from the plant's leaves, rhizosphere, rhizospheres’ soil, and pneumatophore, are mangrove-associated and derived, according to this review. The secondary metabolites produced by fungi originating from mangroves, including alkaloids and polyketides, are discussed in this research, along with how these fungi are the source of bioactive chemicals with potent bioactivities, including antibacterial, anti-inflammatory, antioxidant, antifungal, and anticancer properties.

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