DOI: 10.1039/d3md00441d ISSN: 2632-8682
A survey of stapling methods to increase affinity, activity, and stability of ghrelin analogues
Juan J. Esteban, Julia R. Mason, Jakob Kaminski, Rithwik Ramachandran, Leonard G. Luyt- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science
- Pharmacology
- Molecular Medicine
- Biochemistry
In this paper we present a survey of stapling methods for the peptide ghrelin, resulting in the discovery of ghrelin analogues with improved affinity, stability and efficacy.