DOI: 10.1002/clc.24192 ISSN: 0160-9289

A meta‐analysis investigating the efficacy and adverse events linked to sacubitril‐valsartan in various heart failure subtypes

Qing Ji
  • Cardiology and Cardiovascular Medicine
  • General Medicine



Sacubitril‐valsartan, an inhibitor of the angiotensin receptor neprilysin (ARNi), has been purported to exhibit superiority over angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) in individuals diagnosed with heart failure.


This paper gives an updated meta‐analysis comparing the efficacy and safety of sacubitril‐valsartan to that of standard treatment for different types of heart failure.


The meta‐analysis comprised a total of nine randomized controlled trials (RCTs), incorporating data from a substantial sample size of 15 939 patients. The study observed a decrease in overall mortality and mortality related to cardiovascular causes among patients in the heart failure with reduced ejection fraction (HFrEF) category who were treated with sacubitril‐valsartan. However, no statistically significant variation in this outcome was seen among patients with heart failure with preserved ejection fraction and HFmrEF. Patients who were administered sacubitril‐valsartan had a notably elevated likelihood of experiencing hypotension. Nevertheless, no significant disparities were observed in terms of other adverse events among the various treatment groups.


Current meta‐analysis provide support for use of sacubitril‐valsartan in decreasing mortality in patients with HFrEF. However, more numbers of studies are required to draw a definite conclusion on other benefits associated with sacubitril‐valsartan use over standard treatment of ACE inhibitors and ARBs.

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