DOI: 10.3390/m1756 ISSN: 1422-8599


Dawid J. Kucharski, Przemysław J. Boratyński
  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

An unexpected diastereoselective C-alkylation of a mefloquine derivative in up to 57% yield was the result of an attempted Williamson etherification of Boc-mefloquine. The domino reaction involved oxazolidinone ring closure, deprotonation, and stereoselective carbon–carbon bond formation. The structure was confirmed with 2D NMR experiments.

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