DOI: 10.1111/jmp.12675 ISSN:

Viral evolution of SIV chimpanzee toward HIV‐1 using humanized mice

James Z. Curlin, Kimberly Schmitt, Leila Remling‐Mulder, Corina Valencia Tibbitts, Shelby O'Connor, Preston Marx, Ramesh Akkina
  • General Veterinary
  • Animal Science and Zoology


HIV‐1 emerged from SIVcpz evolving in humans. Humanized mice are an effective tool for assessing viral evolution via measuring viral loads, CD4+ T cell decline, and analyzing genetic changes. Four serial passages showed many non‐synonymous mutations important for the adaptation and evolution of SIVcpz to human immune cells.

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