Alexander Kastner, Theresa Mendrina, Florian Bachmann, Walter Berger, Bernhard K. Keppler, Petra Heffeter, Christian R. Kowol

Tumor-targeted dual-action NSAID-platinum(iv) anticancer prodrugs

  • Inorganic Chemistry

We investigated the first oxaliplatin(iv) complexes releasing acetylsalicylic acid (aspirin) upon reduction. The albumin-targeted derivative showed distinctly improved antitumor activity compared to asplatin, a recently reported cisplatin(iv) analog.

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