DOI: 10.1158/1078-0432.ccr-23-1954 ISSN:
Towards Multiomics-Based Dissection of Anti-EGFR Sensitivity in Colorectal Cancer
Giovanni Randon, Filippo Pietrantonio- Cancer Research
- Oncology
Summary
Overexpression of the EGFR ligands amphiregulin (AREG)/epiregulin (EREG) may be a surrogate of EGFR dependency regardless of sidedness in metastatic colorectal cancer. High AREG/EREG may be coupled with negative hyper-selection (i.e., lack of genomic drivers of primary resistance beyond RAS and BRAF) to identify patients with right-sided tumors and potential sensitivity to EGFR blockade.
See related article by Williams et al., p. xxxx