DOI: 10.1002/em.22572 ISSN:

The Association of Epidermal Growth Factor Variant with Oral Squamous Cell Carcinoma

Baris Ertugrul, Amal Mohammad, Goksu Kasarci, Sinem Bireller, Murat Ulusan, Bedia Cakmakoglu
  • Health, Toxicology and Mutagenesis
  • Genetics (clinical)
  • Epidemiology


In this study, our aim was to investigate the epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR) gene polymorphisms in oral squamous cell carcinoma (OSCC) patients and non‐OSCC healthy controls. This case‐control study comprised 89 OSCC and 107 healthy controls by using polymerase chain reaction (PCR) and restriction‐fragment‐length‐polymorphism methods, the genotypes for EGF +61 A>G (rs4444903) and EGFR R497K (rs2227983) were analyzed. According to the EGF +61 A>G genotype distribution, individuals with the GG genotype were more prevalent in the OSCC group when compared to the healthy controls. But the AA genotype frequency was significantly higher in the healthy control group. The frequency of G allele carriers was 2.3 times higher than A allele carriers in OSCC patients (p<0.001). For the EGFR R497K genotype, there was no significant difference between the OSCC and healthy control groups. Regarding the study results, the G allele of EGF +61 A>G polymorphism was associated with OSCC. Larger populations and functional investigations should be used to explore the nature of the interaction between EGF and OSCC.

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