DOI: 10.1097/iop.0000000000002482 ISSN:

Teprotumumab-related Cutaneous Hypersensitivity Reactions

Liane O. Dallalzadeh, Michelle Ting, Nicole Topilow, Shira L. Robbins, Catherine Y. Liu, Cat N. Burkat, Bobby S. Korn, Don O. Kikkawa
  • Ophthalmology
  • General Medicine
  • Surgery

The authors report 4 cases of cutaneous hypersensitivity reactions developing in the course of teprotumumab treatment for thyroid eye disease. The onset of the cutaneous hypersensitivity reaction was also observed during the treatment course in all cases, between the second and fifth infusions. Teprotumumab-related cutaneous reactions suggest a possible immunogenic component of the monoclonal antibody and highlight the importance of close monitoring during treatment.

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