DOI: 10.1146/annurev.immunol.021908.132706 ISSN:

T Cell Activation

Jennifer E. Smith-Garvin, Gary A. Koretzky, Martha S. Jordan
  • Immunology
  • Immunology and Allergy

This year marks the 25th anniversary of the first Annual Review of Immunology article to describe features of the T cell antigen receptor (TCR). In celebration of this anniversary, we begin with a brief introduction outlining the chronology of the earliest studies that established the basic paradigm for how the engaged TCR transduces its signals. This review continues with a description of the current state of our understanding of TCR signaling, as well as a summary of recent findings examining other key aspects of T cell activation, including cross talk between the TCR and integrins, the role of costimulatory molecules, and how signals may negatively regulate T cell function.

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