DOI: 10.1155/2023/3360310 ISSN:

IL-17: Balancing Protective Immunity and Pathogenesis

Lu Sun, Lufei Wang, Bethany B. Moore, Shaoping Zhang, Peng Xiao, Ann M. Decker, Hom-Lay Wang
  • Immunology
  • General Medicine
  • Immunology and Allergy

The biological role of interleukin 17 (IL-17) has been explored during recent decades and identified as a pivotal player in coordinating innate and adaptive immune responses. Notably, IL-17 functions as a double-edged sword with both destructive and protective immunological roles. While substantial progress has implicated unrestrained IL-17 in a variety of infectious diseases or autoimmune conditions, IL-17 plays an important role in protecting the host against pathogens and maintaining physiological homeostasis. In this review, we describe canonical IL-17 signaling mechanisms promoting neutrophils recruitment, antimicrobial peptide production, and maintaining the epithelium barrier integrity, as well as some noncanonical mechanisms involving IL-17 that elicit protective immunity.

More from our Archive