DOI: 10.3390/gels9080653 ISSN:

Self-Assembled Peptide Hydrogels in Regenerative Medicine

Shuangyang Li, Qixuan Yu, Hongpeng Li, Meiqi Chen, Ye Jin, Da Liu
  • Polymers and Plastics
  • Organic Chemistry
  • Biomaterials
  • Bioengineering

Regenerative medicine is a complex discipline that is becoming a hot research topic. Skin, bone, and nerve regeneration dominate current treatments in regenerative medicine. A new type of drug is urgently needed for their treatment due to their high vulnerability to damage and weak self-repairing ability. A self-assembled peptide hydrogel is a good scaffolding material in regenerative medicine because it is similar to the cytoplasmic matrix environment; it promotes cell adhesion, migration, proliferation, and division; and its degradation products are natural and harmless proteins. However, fewer studies have examined the specific mechanisms of self-assembled peptide hydrogels in promoting tissue regeneration. This review summarizes the applications and mechanisms of self-assembled short peptide and peptide hydrogels in skin, bone, and neural healing to improve their applications in tissue healing and regeneration.

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