DOI: 10.1111/cts.13621 ISSN:

Sarcopenia assessed by CT or MRI is associated with the loss of response to biologic therapies in adult patients with Crohn's disease

Jingjing Liu, Hongye Tang, Tingting Lin, Jiangchuan Wang, Wenjing Cui, Chao Xie, Zhongqiu Wang, Yugen Chen, Xiao Chen
  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry, Genetics and Molecular Biology
  • General Medicine
  • General Neuroscience


Sarcopenia occurs in patients with Crohn's disease (CD). However, the association between sarcopenia and loss of response (LOR) to biologic agents remains unclear. This study explored such association in CD patients. This retrospective study included 94 CD patients who received biologic therapy. The skeletal muscle cross‐sectional area at the third lumbar was assessed by computed tomography or magnetic resonance imaging for sarcopenia evaluation. An LOR was defined by fecal calprotectin (FC) < 250 μg/g or > 50% reduction from baseline levels or other factors, such as the used agent being replaced by other biologic agents. The association between sarcopenia and LOR was assessed by logistic regression analysis. LOR was observed in 54 patients (57.4%). The prevalence of sarcopenia in LOR group was higher than that in response group (70.4% vs 40.0%, p = 0.003). Sarcopenia (odds ratio (OR) = 3.89, 95% confidence interval (CI): 1.31‐11.54), Montreal L1 type (OR = 0.20, 95% CI: 0.06‐0.60), perianal lesions (OR = 4.08, 95% CI: 1.31‐12.70) and monocytes percentage (OR = 1.27, 95% CI: 1.02‐1.57) at baseline were independent associated factors for LOR. Sarcopenia was also associated with LOR in patients who received infliximab (OR = 3.31, 95% CI: 1.11‐9.87). Montreal L1 type, perianal lesions and monocyte percentage (model one), and with additional consideration of sarcopenia (model two) were developed to predict LOR. Model two showed better performance than model one (area under the curve, 0.82 vs 0.75). Sarcopenia was associated with the LOR to biological agents or infliximab in adult patients with CD.

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