Outer retinal microcavitations in Retinitis Pigmentosa: a novel OCT finding common in RP1-related retinopathy.
Ioannis S. Dimopoulos, Laryssa A. Huryn, Robert B. Hufnagel, Ehsan Ullah, Aime R. Agather, Delphine Blain, Brian P. Brooks, Catherine A. Cukras, Wadih M. Zein- Ophthalmology
- General Medicine
PURPOSE.
To describe a novel optical coherence tomography (OCT) finding of outer retina microcavitations in
METHODS.
Medical charts and OCT images of 28 patients with either autosomal dominant (adRP) or recessive (arRP)
RESULTS.
Among 15 included patients, microcavitations were found in at least one eye of all arR patients and 7/12 (58%) of adR patients. Patients with adR and microcavitations were older at the time of examination (51 vs. 43 years of age; p=0.04) and their eyes demonstrated worse BCVA (0.09 vs. 0 logMAR; p=0.008), reduced CSF (256 vs. 293μm; p=0.01), AMT (241 vs. 270μm; p=0.02) and shorter transfoveal EZ widths (1.67 vs. 4.98mm; p<0.0001). The finding of microcavitations showed a specificity of 0.92 for
CONCLUSION.
A novel OCT finding of outer retina microcavitations was commonly observed in patients with