DOI: 10.1166/jbt.2023.3306 ISSN:

Nursing Intervention in Oral Mucositis After Methotrexate Chemotherapy in Children with Hematological Tumors

Benying Yu, Lin Du, Wenyan Chen, Banghong Xu
  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Bioengineering
  • Biotechnology

Objective: To explore the nursing intervention and its clinical effect on oral mucositis after methotrexate (MTX) chemotherapy in children with hematological tumors. Methods: Two-hundred children with hematological tumors admitted to Nanjing Children’s Hospital between January 2021 and August 2022 and treated with MTX chemotherapy after admission randomly dividing as control and experimental groups (n = 100 every group). Children given conventional clinical nursing and comprehensive oral care. Oral ulcer, quality of life, and satisfaction of children’s parents after intervention were compared between 2 groups. Results: SF-36 score after nursing intervention significantly increasing in experimental group compared with that of control group, with a statistically significant difference (p<0.05). Satisfaction of children’s parents significantly improving in experimental group compared with that of control group (p<0.05). Conclusion: Comprehensive oral nursing intervention is effective in preventing and treating oral mucositis, improving oral cleanliness and comfort, and developing good oral hygiene habits, which is conducive to clinical rehabilitation in children undergoing MTX chemotherapy for hematological tumors.

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