DOI: 10.1097/meg.0000000000002729 ISSN: 0954-691X

Myosteatosis is an independent risk factor for overt hepatic encephalopathy after transjugular intrahepatic portosystemic shunting

Wenfeng Shi, Hua Yin, Zhijian Yu, Yong Li, Xiao Bai, Sirui Fu, Chongyang Duan, Weiguo Xu, Yang Yang
  • Gastroenterology
  • Hepatology


The relationship between skeletal muscle and adipose tissue compositions and risk of overt hepatic encephalopathy (OHE) following transjugular intrahepatic portosystemic shunt (TIPS) treatment needs to be investigated.


A total of 282 patients were collected from two medical centres. The median time of follow-up was 48.23 + 1.36 months and the first-year results of all patients after TIPS therapy were collected. The muscle and adipose tissue indices were quantified at the third lumbar vertebra level. Sarcopenia and myosteatosis were defined according to previous researches. Receiver operating characteristic curves, chi-square test, univariate and multivariate logistic regression analyses were employed to investigate the potential association between muscle and adipose indices, sarcopenia, myosteatosis and the risk of developing post-TIPS OHE.


All skeletal muscle indices, adipose tissue indices and sarcopenia had limited associations with post-TIPS OHE. Myosteatosis (148 cases, 52.5%, 55 with OHE, 37.2%) was identified as an independent risk factor for post-TIPS OHE. with P < 0.001 in Chi-square test, P < 0.001, odds ratio (OR): 2.854, 95% confidence interval (CI): 1.632–4.993 in univariate logistic regression analyses, and P = 0.007, OR: 2.372, 95% CI: 1.268–4.438 in multivariate logistic regression analyses, respectively.


Our results showed that myosteatosis was proven as an independent risk factor for the development of post-TIPS OHE.

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