DOI: 10.1084/jem.133.2.275 ISSN:

ISOLATION OF A TUMOR FACTOR RESPONSIBLE FOR ANGIOGENESIS

Judah Folkman, Ezio Merler, Charles Abernathy, Gretchen Williams
  • Immunology
  • Immunology and Allergy
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Human and animal solid tumors elaborate a factor which is mitogenic to capillary endothelial cells. This factor has been called tumor-angiogenesis factor. The important components of TAF are RNA and protein. It is suggested that blockade of this factor (inhibition of angiogenesis) might arrest solid tumors at a tiny diameter of a few millimeters.

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