DOI: 10.1128/jb.85.6.1274-1279.1963 ISSN:
NEISSERIA GONORRHOEAE I
Douglas S. Kellogg, William L. Peacock, W. E. Deacon, L. Brown, Carl I. Pirkle- Molecular Biology
- Microbiology
Kellogg, Douglas S., Jr.
(Communicable Disease Center, Atlanta, Ga.),
William L. Peacock, Jr., W. E. Deacon, L. Brown, and Carl I. Pirkle
.
Neisseria gonorrhoeae
. I. Virulence genetically linked to clonal variation. J. Bacteriol.
85:
1274–1279. 1963.—One type, obtained from the purulent exudate of acute gonorrhea was maintained by 69 selective in vitro passages, at which point the organisms produced infections in human volunteers. A predominance of clonal types found in laboratory strains and a lack of ability to infect human volunteers resulted from 69 nonselective in vitro passages. Physiological and serological characteristics of the clonal types are compared. We are now in a position to study
Neisseria gonorrhoeae
organisms in their virulent form.