Katerina Gavriel, Dustin C. A. van Doeselaar, Daniëlle W. T. Geers, Kevin Neumann

Click’n lock: rapid exchange between unsymmetric tetrazines and thiols for reversible, chemoselective functionalisation of biomolecules with on-demand bioorthogonal locking

  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Molecular Biology
  • Biochemistry
  • Chemistry (miscellaneous)

Click’n lock describes a reaction system capable of switching on-demand from reversible to irreversible click reactions and is based on the chemoselective tetrazine–thiol exchange. Here, click’n lock is applied for dynamic modifications of peptides.

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