Hydrogels Loaded with Atorvastatin‐Metal Organic Framework Have a Preventive Effect on Coronary Heart Disease

Abstract

In the research, a new three‐dimensional coordination polymer was synthesized by solvothermal method based on the metal ligand L^Cu=[Cu(2,4‐pydca)₂]²⁻ (2,4‐pydca=pyridine‐2,4‐dicarboxylate) and alkaline‐earth ion Ca^II with chemical composition {[Ca(H₂O)₂][L^Cu]⋅DMSO ⋅ 2H₂O}_n (1) (DMSO=dimethyl sulfoxide). The complex 1 was characterized soundly by Fourier transform infrared (FT‐IR) spectroscopy, elemental analysis (EA), single‐crystal X‐ray diffraction (SCXRD) and thermogravimetric analysis (TGA). Using atorvastatin as drug model, carboxymethyl chitosan and calcium alginate as raw materials, a new type of metal gel particles was prepared. The microstructure of the gel was observed by scanning Electron Microscope (SEM) and its modulation effect on the activity of human cardiomyocytes was evaluated. The results show that the gel particles presented a three‐dimensional porous structure and were able to significantly up‐regulate the cell activity of human cardiomyocytes, which is expected to develop the metal gel particles into drugs for the treatment of coronary heart disease.