AbstractAimsWe evaluated whether Subjective Cognitive Decline (SCD) subtypes could be empirically derived within the Sino Longitudinal Study on Cognitive Decline (SILCODE) SCD cohort and examined associated neuroimaging markers, biomarkers, and clinical outcomes.MethodsA cluster analysis was performed on eight neuropsychological test scores from 124 SCD SILCODE participants and 57 normal control (NC) subjects. Structural and functional neuroimaging indices were used to evaluate the SCD subgroups.ResultsFour subtypes emerged: (1) dysexecutive/mixed SCD (n = 23), (2) neuropsychiatric SCD (n = 24), (3) amnestic SCD (n = 22), and (4) cluster‐derived normal (n = 55) who exhibited normal performance in neuropsychological tests. Compared with the NC group, each subgroup showed distinct patterns in gray matter (GM) volume and the amplitude of low‐frequency fluctuations (ALFF). Lower fractional anisotropy (FA) values were only found in the neuropsychiatric SCD group relative to NC.ConclusionThe identification of empirically derived SCD subtypes demonstrates the presence of heterogeneity in SCD neuropsychological profiles. The cluster‐derived normal group may represent the majority of SCD individuals who do not show progressive cognitive decline; the dysexecutive/mixed SCD and amnestic SCD might represent high‐risk groups with progressing cognitive decline; and finally, the neuropsychiatric SCD may represent a new topic in SCD research.

More from our Archive

• DOI: 10.3390/vaccines11081304 2023

  Next-Generation TB Vaccines: Progress, Challenges, and Prospects

  Li Zhuang, Zhaoyang Ye, Linsheng Li, Ling Yang, Wenping Gong

• DOI: 10.3390/vaccines11081298 2023

  Pustular Eruption following COVID-19 Vaccination: A Narrative Case-Based Review

  Emmanouil Karampinis, Agoritsa Gravani, Polyxeni Gidarokosta, Dimitrios Petros Bogdanos, Angeliki-Viktoria Roussaki-Schulze, Efterpi Zafiriou

• DOI: 10.1111/apt.17653 2023

  Diabetes impairs the haemodynamic response to non‐selective betablockers in compensated cirrhosis and predisposes to hepatic decompensation

  Rafael Paternostro, Mathias Jachs, Lukas Hartl, Benedikt Simbrunner, Bernhard Scheiner, David Bauer, Philipp Schwabl, Georg Semmler, Michael Trauner, Mattias Mandorfer, Thomas Reiberger

• DOI: 10.1093/rheumatology/kead377 2023

  Increased risk of cardiovascular disease preceding diagnosis of incident ANCA-associated vasculitis: a Danish nationwide study

  Louis Nygaard, Christoffer Polcwiartek, Karl Emil Nelveg-Kristensen, Nicholas Carlson, Salome Kristensen, Christian Torp-Pedersen, Jon Waarst Gregersen,

• DOI: 10.3390/vaccines11081328 2023

  Tracing down the Updates on Dengue Virus—Molecular Biology, Antivirals, and Vaccine Strategies

  Shiza Malik, Omar Ahsan, Hassan Mumtaz, Muhammad Tahir Khan, Ranjit Sah, Yasir Waheed

• DOI: 10.1002/phar.2859 2023

  Anticoagulation strategies in patients with extracorporeal membrane oxygenation: A network meta‐analysis and systematic review

  Jiale Chen, Guoquan Chen, Wenyi Zhao, Wenxing Peng

• DOI: 10.3390/antibiotics12081280 2023

  Repurposing of Nitroxoline as an Alternative Primary Amoebic Meningoencephalitis Treatment

  Javier Chao-Pellicer, Iñigo Arberas-Jiménez, Frieder Fuchs, Ines Sifaoui, José E. Piñero, Jacob Lorenzo-Morales, Patrick Scheid

• DOI: 10.3390/antibiotics12081283 2023

  Site Mutation Improves the Expression and Antimicrobial Properties of Fungal Defense

  Ya Hao, Da Teng, Ruoyu Mao, Na Yang, Jianhua Wang

• DOI: 10.3390/antibiotics12081264 2023

  Nanosilver: An Old Antibacterial Agent with Great Promise in the Fight against Antibiotic Resistance

  Kyra G. Kaiser, Victoire Delattre, Victoria J. Frost, Gregory W. Buck, Julianne V. Phu, Timea G. Fernandez, Ioana E. Pavel

• DOI: 10.1177/02698811231181573 2023

  Postpartum psychosis: A proposed treatment algorithm

  Chaitra Jairaj, Gertrude Seneviratne, Veerle Bergink, Iris E Sommer, Paola Dazzan