Formulation and evaluation of taste-masked oral disintegrating tablet containing tolterodine-loaded montmorillonite
Somayeh Taymouri, Abolfazl Mostafavi, Homa Talabaki- General Pharmacology, Toxicology and Pharmaceutics
Background and purpose:
The present study aimed to obtain a taste-masked oral disintegrating tablet (ODT) containing tolterodine tartrate (TT) intercalated into montmorillonite (MMT)
Experimental approach:
The TT-MMT hybrid was prepared by ion exchange reaction. The effect of the initial concentration of TT, MMT, temperature, and pH on the encapsulation efficiency (EE) % of the drug in MMT was evaluated. The selected TT-MMT hybrid was characterized by X-ray diffraction (XRD), Fourier transforms infrared (FTIR), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM). Then, the optimized TT-MMT hybrid was incorporated in the ODT prepared by direct compression method and taste-masking assessment performed by a human test panel.
Findings/Results:
The EE% of TT was in the range of 22.67 to 71.06% in different formulations. It was found that increases in MMT concentration significantly increased EE%. DSC and XRD studies indicated that the TT was intercalated in the MMT interlayer space in an amorphous or molecular state.
Conclusion and implications:
MMT-ODT could be a suitable vehicle for the taste masking of TT, with the potential for use in patients with swallowing problems.