DOI: 10.1039/d3ra06614b ISSN: 2046-2069
Five and six membered heterocyclic rings endowed with azobenzene as dual EGFRT790M and VEGFR-2 inhibitors: design, synthesis, in silico ADMET profile, molecular docking, dynamic simulation and anticancer evaluations
Kurls E. Anwer, Sanadelaslam S. A. El-Hddad, Nour E. A. Abd El-Sattar, Ahmed El-morsy, Fathalla Khedr, Samy Mohamady, Doaa E. Keshek, Samir A. Salama, Khaled El-Adl, Noura S. Hanafy- General Chemical Engineering
- General Chemistry
Novel azobenzene scaffold-joined heterocyclic isoxazole, pyrazole, triazole, and/or triazine moieties have been developed and synthesized utilizing microwave and traditional methods.