Expression and clinical significance of Cat B and sICAM-1 in the GCF of patients with peri-implantitis
Qinglian Wang, Jichao Lin, Yanjun Lin, Youcheng Yu- General Engineering
- Condensed Matter Physics
- General Materials Science
Background:
Peri-implantitis is an irreversible disease occurring in the tissues surrounding dental implants, and it is characterized by decreased osseointegration, progressive bone loss, bone resorption, and increased pocket formation and purulence.
Objective:
This study was conducted to elucidate the expression and clinical significance of Cat B and sICAM-1 in the gingival crevicular fluid (GCF) of patients with peri-implantitis.
Methods:
A total of 154 patients, who underwent implant denture treatment in our hospital, were selected as the research subjects. They were divided into a peri-implantitis group (65 cases) and a healthy implant group (89 cases) according to whether there was inflammation around the implant. All subjects were assessed for periodontal clinical indicators (plaque index (PLI), probing depth (PD), clinical attachment level (CAL), and sulcus bleeding index (SBI)). The levels of inflammatory factors (IL-1β, TNF-α, and IL-6) and Cat B and sICAM-1 in the GCF were measured using an enzyme-linked immunosorbent assay. Pearson test was used to analyze the correlation between the levels of Cat B and sICAM-1 in GCF and PD, SBI, CAL, PLI, IL-1β, TNF-α, and IL-6. ROC curve was used for the evaluation of the diagnostic accuracy of Cat B and sICAM-1 for peri-implantitis.
Results:
Patients in the peri-implantitis group presented increased PD, SBI, CAL, PLI, and levels of IL-1β, TNF-α, IL-6, Cat B, and sICAM-1 in GCF in comparison to those in the healthy implant group (P < 0.05). Pearson test exhibited that the levels of Cat B and sICAM-1 in the GCF were positively correlated with PD, SBI, CAL, PLI, IL-1β, TNF-α, and IL-6. ROC analysis revealed that the area under the curve for Cat B and sICAM-1 levels alone and in combination were 0.798, 0.741, and 0.829, respectively, with sensitivity of 58.46%, 55.38%, and 73.85% and the specificity of 91.01%, 89.89%, and 84.27%, respectively.
Conclusion:
Our study demonstrates that Cat B and sICAM-1 are upregulated in the GCF of patients with peri-implantitis and correlate with the inflammation level and the degree of disease, and have a predictive value in the development of peri-implantitis.
Other:
Cat B and sICAM-1 have certain diagnostic abilities for peri-implantitis. However, further experiments with a larger number of subjects are necessary to elucidate whether these molecules could be served as vital biomarkers of peri-implantitis.