DOI: 10.1039/d3md00044c ISSN: 2632-8682
Enhancing allosteric inhibition of dihydrodipicolinate synthase through the design and synthesis of novel dimeric compounds
Rebecca M. Christoff, Mohammad Al Bayer, Tatiana P. Soares da Costa, Matthew A. Perugini, Belinda M. Abbott- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science
- Pharmacology
- Molecular Medicine
- Biochemistry
The synthesis of the first low micromolar dimeric inhibitor of E. coli DHDPS is reported.