Xinyi Chen, Sitian Liu, Mingying Han, Meng Long, Ting Li, Lanlan Hu, Ling Wang, Wenhua Huang, Yaobin Wu

Engineering Cardiac Tissue for Advanced Heart‐On‐A‐Chip Platforms

  • Pharmaceutical Science
  • Biomedical Engineering
  • Biomaterials
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AbstractCardiovascular disease is a major cause of mortality worldwide, and current preclinical models including traditional animal models and 2D cell culture models have limitations in replicating human native heart physiology and response to drugs. Heart‐on‐a‐chip (HoC) technology offers a promising solution by combining the advantages of cardiac tissue engineering and microfluidics to create in vitro 3D cardiac models, which can mimic key aspects of human microphysiological systems and provide controllable microenvironments. Herein, recent advances in HoC technologies are introduced, including engineered cardiac microtissue construction in vitro, microfluidic chip fabrication, microenvironmental stimulation, and real‐time feedback systems. The development of cardiac tissue engineering methods is focused for 3D microtissue preparation, advanced strategies for HoC fabrication, and current applications of these platforms. Major challenges in HoC fabrication are discussed and the perspective on the potential for these platforms is provided to advance research and clinical applications.

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