DOI: 10.1039/d3ra07836a ISSN: 2046-2069
Electronic substituent effect on the conformation of a phenylalanine-incorporated cyclic peptide
Akiko Asano, Yukiko Kawanami, Mao Fujita, Yuta Yano, Rio Ide, Katsuhiko Minoura, Takuma Kato, Mitsunobu Doi- General Chemical Engineering
- General Chemistry
Using a Phe-incorporated cyclic peptide as a scaffold, we discussed the local control of CH⋯π interactions and the associated flexibility of the Phe side chain by the 4-position substituents and their effects on global conformational equilibrium.