DOI: 10.1039/d3ob00963g ISSN: 1477-0520
Effects of chirality and side chain length in Cα,α-dialkylated residues on β-hairpin peptide folded structure and stability
Shelby L. Heath, W. Seth Horne, George A. Lengyel- Organic Chemistry
- Physical and Theoretical Chemistry
- Biochemistry
A Cα,α-dialkylated residue with appropriate stereochemical configuration can associate with the hydrophobic core of a β-hairpin peptide, providing additional stability.